Health-related goals have been central to the Millennium Development Goals and the Sustainable Development Goals, yet progress has been uneven. Public health gaps remain most pronounced in the Global South, where severe capacity and resource constraints persist. The rise of digitized health data, alongside declining computational costs, is enabling innovation through AI models trained on historical data. However, concerns about safety, privacy, and exclusion continue to surround digital health advances. Beyond technological and financial infrastructure, social innovation in health offers a transformative approach by elevating community-driven solutions, particularly in vulnerable contexts. In this context, GlobalDev at the Global Development Network (GDN), the Social Innovation Hub for Health in LAC (SIHILAC) and the Health AI for All Network (HAINet) invite researchers to draw on their work and available evidence to submit blog posts on public health innovations that strengthen health systems, improve access and universal health coverage, and transform health service delivery in resource-limited settings.